HSP Research Foundation

Welcome to the HSP Research Foundation – created in 2005 to find an effective treatment for Hereditary Spastic Paraplegia (HSP) – an inherited, degenerative disease affecting mainly the legs, causing spasticity, muscle weakness and severely impairing walking.

The HSP Research Foundation is an incorporated, registered Australian charity that facilitates and funds research to find an effective treatment. The Foundation is also the community hub for HSPers in Australia, creating awareness and providing information, education and support. Read More »

Winter Edition 2020

Spring edition to be published early September 2020

Reduced axon transport in SPG4 degeneration

Consequence of higher sensitivity to oxidative stress

Importance of lipid droplet metabolism in HSP

Fundamental processes and potential drug targets

1 comment

Mechanism of AP-4 related HSPs clarified

Applies to HSP types 47, 50, 51 and 52

SPG52 found in people with cerebral palsy

Three new mutations identified

2 cases of SPG9 related to pregnancy

Amino acid deficiency found

SPG11 mechanism examined in depth

Initial impact is early in neurodevelopment

New HSP genotypes and phenotypes

Research from Poland, Sudan, Spain, Iran, Korea, China, Czech Republic, Taiwan, Turkey, Mexico and Italy

SPG7 MRI pattern linked to mental function

Cognitive and social/emotional impairment found

Results of Annual Survey of HSPers

Data on wellbeing, mobility, medication

COVID-19, stress & gait deterioration

HSPers share their experiences

Combined Botox & physio treatment success

Improvement in spasticity & quality of life

The burden of living with pure HSP

Large survey conducted in the Netherlands

HSP clinical trial program update June 2020

Progress in pre-clinical studies

4 comments

NDIS update June 2020

More flexibility with using funds

COVID-19 Impact Survey

HSP families invited to participate

COVID-19 journal study

Participation invited

Rural Fire Service volunteer with HSP

Challenges faced with the bushfires

Melbourne HSPer tries footy

Hawthorn AFL Club program

Tom Wahlig Foundation grants 2020

3 first-class proposals receive funding

Your Say »

This space is for you to have your say. Email us

Dictus Bands

Has anyone else here tried Dictus Bands?

4 comments

Speech difficulties with HSP

Has anyone been to a speech pathologist?

8 comments

Medical cannabis

Anyone tried it for HSP?

29 comments

Here are 3 of the more than 700 community members

Foundation Research Team

Here are the researchers working on the HSP Research Program facilitated and funded by the Foundation

Fundraising for HSP Research

Pre-clinical investigations leading into clinical trials are the current focus of the HSP Research Program. The aim is to find out if the drug treatment effective with HSP stem cells in the lab is effective with HSPers themselves.

There are technical, medical, ethical, regulatory, logistical, legal, financial and organisational challenges to address and take action on. Biomarker studies to find a measure for HSP are underway and drug dose range finding studies are now completed.

Consistent funding support helps attract outside funding. We need to reach $120,000 again in 2020.

An effective treatment for HSP is now within reach!