Potential drug candidate for AP-4 HSPs identified
AP-4 blood biomarker discovered also
4 commentsHSP Research Foundation
Welcome to the HSP Research Foundation – created in 2005 to find an effective treatment for the Hereditary Spastic Paraplegias (HSPs) – a group of progressive, inherited, degenerative diseases affecting mainly the legs, causing spasticity, muscle weakness and severely impairing walking.
The HSP Research Foundation is an incorporated, registered Australian charity that facilitates and funds research to find effective treatments and cures. The Foundation is also the community hub for people with HSP in Australia, creating awareness and providing information, education and support. Read more »
Spring Edition 2023
A new website is under development
Research highlights »
Potential imaging biomarkers of HSP progression
Peripheral nerve involvement in SPG4 & SPG7
Lipid balance disrupted in SPG89
Approved statins may help fix the problem
Computer simulation of gait in early-stage SPG4
Marker of disease severity / treatment effectiveness
2 commentsMethodology established to quantify gait in HSP
Single lower-back wearable inertial sensor used
Is it HSP, CMT, PLS or ALS?
Gene testing helps with diagnosis
Mouse study of SPG8 disease mechanism
Protein regulates structural plasticity of neurons
High phenotype variability in SPG3A examined
Other genes & epigenetics play a part
New HSP genotypes & phenotypes
Research from Taiwan, Spain, China, France, USA, South Korea, Italy, Turkiye, India and Brazil
Living with HSPmanagement & treatment news »
AKV9 (NU-9) approved for clinical trial
Phase 1 study in humans
37 commentsFunding for HSP gene therapy
Expansion of SPG50 clinical trials
Accessibility Mapping of Kalgoorlie
Another project with community member Jason
Balance exercises for HSP
Improve walking, help prevent falls
4 commentsAn irreverent view of life from a wheelchair
HSP community member writes a book
Adaptive Climbing – a sport for all
Even for those in wheelchairs
Dating with a disability
An individual reflection
2 commentsFoundation News »
Recognition for Alan Mackay-Sim
2023 ‘Queensland Greats’ award
1 commentSPF Conference 2023 USA
Latest research presentations
Social gatherings on the rise
Get-togethers in NSW, Vic, ACT, WA & Qld
NDIS update September 2023
Big changes coming
1 commentAccessible toilets on single-aisle aircraft
New regulations a step in right direction
Clinical trial reporting rules being flouted
US Government enforcement improving compliance