Compound stops neuron degeneration
Potential relevance for HSP, PLS, MND
6 commentsHSP Research Foundation
Welcome to the HSP Research Foundation – created in 2005 to find an effective treatment for Hereditary Spastic Paraplegia (HSP) – an inherited, degenerative disease affecting mainly the legs, causing spasticity, muscle weakness and severely impairing walking.
The HSP Research Foundation is an incorporated, registered Australian charity that facilitates and funds research to find an effective treatment. The Foundation is also the community hub for HSPers in Australia, creating awareness and providing information, education and support. Read more »
Spring Edition 2021
Summer edition to be published early December 2021
Research highlights »
Brain damage ‘a conspicuous feature’ of HSP
Different damage patterns depending on type
Identifying common impaired cell functions in HSP
Future drug treatments for multiple types
Common mechanisms in HSP & other conditions
Understanding key to finding cures
Major advance in gene therapy
Potential for editing genes directly
Improving Diagnosis, biomarkers & drug discovery
Cell morphology & machine learning
Mitochondria affected in SPG11
Altered structure, function & transport found
Challenges in genetic diagnosis of HSP
Improved genetic testing strategies the key
Huge collaboration and “big” data
Combining to solve rare diseases
Potential diagnostic HSP biomarker
Differences with gender and age identified
HSPs include a broad spectrum
Clinical & genetic overlap with Ataxias
Potential new HSP gene
GCH1 gene recommended for HSP panels
HSPer with sleep disorder
Possibly associated with SPG4
New HSP genotypes and phenotypes
Research from Germany, UK, Taiwan, Sweden, Italy, Saudi Arabia, China, Czech Republic, Iran, USA, Austria, Belgium, the Netherlands, Egypt, Pakistan, France, Japan, Turkey, Russia, Ireland, India
Living with HSPmanagement & treatment news »
Choosing an IVF clinic
New comparison website will help
Children with HSP and CP compared
Support for similar treatment approaches
Navigating between love and fear
Dual role of parent & caregiver
Results of worldwide survey of HSPers
Well-being, mobility, diagnosis & treatments
Botox treatment for spasticity improves lives
600 surveyed for their experience
Mental health awareness
Different parts of the puzzle
Getting CBD in Australia
Is it legal? Is it available?
Horse riding therapy for HSP
Significant benefits reported
Dating with a disability
Insights for all
Former Ireland wicket-keeper has HSP
Talks about living with the condition
Foundation News »
Research program update September 2021
Challenging environment for progress
Fundraising in 2021
On the way to a record year
1 commentDeveloping therapies & preventative strategies
Top priority for people with rare neurological diseases
HSPer works with sick kids
So does her dog!
Talking about disability
2 Models & 4 Golden Rules
Commercial considerations undermining drug development
Rare disease communities most affected
US & UK HSP support groups
Latest Newsletters
NDIS Update September 2021
Concern mounting
