Gene therapy under development for SPG49
Successfully tested in primates
HSP Research Foundation
Welcome to the HSP Research Foundation – created in 2005 to find an effective treatment for the Hereditary Spastic Paraplegias (HSPs) – a group of progressive, inherited, degenerative diseases affecting mainly the legs, causing spasticity, muscle weakness and severely impairing walking.
The HSP Research Foundation is an incorporated, registered Australian charity that facilitates and funds research to find effective treatments and cures. The Foundation is also the community hub for people with HSP in Australia, creating awareness and providing information, education and support. Read more »
Spring Edition 2022
Summer edition to be published early December 2022
Research highlights »
Neuroinflammation important in SPG11
Responsive to drug treatment in animal testing
Neuropsychology of SPG11 studied
Verbal fluency, memory & executive functions impaired
SPG3A & MS found in 9 cases
Positive response to immunotherapy for most
Recessive SPG87 both pure & complex forms
Mitochondria & endoplasmic reticulum impairments found
SPG56 mouse studies provide insight
Diagnostic biomarkers & possible treatments identified
SPG80 mice show HSP symptoms
Insight into how SPG80 is caused
2 commentsNew HSP genotypes and phenotypes
Research from USA, Germany, Turkey, China, India, France, Japan, Austria
Living with HSPmanagement & treatment news »
R U OK?
Help if you’re feeling down
Sex and disability
New book on the topic
Mindfulness practice can reduce pain
Separating pain from suffering is key
IVF for HSP parents
Having children free of HSP
Brain & Life online magazine
Helpful articles for HSP
Getting old is hard
Preventing functional decline and injury
Better understanding spasticity
Exercise and stretching that can help
Physical activity good for disability
Evidence that it improves quality of life
Foundation News »
Research program update September 2022
Progress with assays and biomarkers
Gene therapies for children with HSP
High hopes for success & widespread application
4 commentsHuman Genome now fully mapped
Gene therapies must develop faster
1 commentUpdate on promising drug NU-9
Positive results in mouse studies
SP Foundation July 2022 Conference
All the sessions on YouTube
AI leads to protein breakthrough
Structure of folded human proteins mapped
NDIS Update September 2022
Challenges to success of the scheme increasing
HSP groups in the US & Germany
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