HSP Research Foundation

Welcome to the HSP Research Foundation – created in 2005 to find an effective treatment for Hereditary Spastic Paraplegia (HSP) – an inherited, degenerative disease affecting mainly the legs, causing spasticity, muscle weakness and severely impairing walking.

The HSP Research Foundation is an incorporated, registered Australian charity that facilitates and funds research to find an effective treatment. The Foundation is also the community hub for HSPers in Australia, creating awareness and providing information, education and support. Read More »

Summer Edition 2020

Autumn edition to be published early March 2021

Cell mechanism behind SPG7 discovered

Drug treatment to correct impairment identified

3 studies of SPG4 mechanisms

Shedding light on treatment targets

AP-4 related childhood-onset, complex HSP

Covers SPG47, SPG50, SPG51 and SPG52

ER stress associated with SPG31

Mice with SPG31 have functions restored with treatment

Impaired mitochondria SPG61

Division (fission) problems in mitochondrial network

Lower motor neuron degeneration in HSP?

Findings of electrophysiological studies

New HSP genotypes & phenotypes

Research from the Netherlands, China, Hungary, USA, Republic of Korea, Chile, Germany, Argentina, Japan, Peru, Spain, France and Brazil

2 comments

Loneliness & isolation with disability

And what you can do about it

UK Annual HSP Survey

HSPers everywhere invited

Siblings of people with disability

Challenges and needs of the sibling role

Robotic gait rehabilitation therapy

World first device in Sydney

Physios & OTs largely unfamiliar with HSP

Brief instruction found to help

Poorer health services for HSP

Linked to limited HSP knowledge

SPG4 Clinical trial plans discussed

Q&A session at Foundation AGM

Royal Commission on Disability

Negative findings in Covid response report

NDIS update December 2020

New assessment process concerns

Disability advocacy funding NSW

$112 million committed over 4 years

US & UK HSP support groups

Latest Newsletters

Your Say »

This space is for you to have your say. Email us

Dictus Bands

Has anyone else here tried Dictus Bands?

5 comments

Speech difficulties with HSP

Has anyone been to a speech pathologist?

8 comments

Medical cannabis

Anyone tried it for HSP?

33 comments

Here are 3 of the more than 700 community members

Foundation Research Team

Here are the researchers working on the HSP Research Program facilitated and funded by the Foundation

Fundraising for HSP Research

Biomarker studies and advanced planning for clinical trials are the current focus of the HSP Research Program. The aim is to find out if the drug treatment effective with HSP stem cells in the lab is effective with HSPers themselves.

There are technical, medical, ethical, regulatory, logistical, legal, financial and organisational challenges to address and take action on. The Foundation is fully committed to pushing ahead despite restrictions and limitations imposed by the global coronavirus pandemic.

Consistent funding support helps attract outside funding. We need to reach $120,000 again in 2020 and we need your support now more than ever.

An effective treatment for HSP is now within reach!