Treated with drug therapy
A drug therapy, Topiramate, has been used to treat tremor, which rarely occurs in HSP, but is reported in this case of a girl with SPG15 HSP.
Hereditary spastic paraplegia (HSP) is group of a rare neurodegenerative disorder with both genetically and clinically diverse neurologic features. Indeed, disease progression varies greatly within the different forms and current treatment modalities are exclusively for symptoms of HSP.
Tremor in HSP patients is only mentioned with rare case reports, so treatment options lack clinical grounding. We report a case of a HSP-15 girl with a previously reported novel mutation of SPG15 complaining of a life disturbing tremor and topiramate as a drug therapy for tremor in our HSP patient.
SOURCE: Clin Neuropharmacol. Jul/Aug 2020;43(4):121-122. doi: 10.1097/WNF.0000000000000392. PMID: 32501858
Topiramate-Responsive Tremor in a Novel Pathogenic Variant of SPG15 Patient
Atilla Ersen 1, Pınar Gençpınar 2, Pınar Arıcan 3, Sema Bozkaya Yılmaz 1, Nargiz Aliyeva 1, Taha Reşid Özdemir 4, Özgür Öztekin 5, Nihal Olgaç Dündar 2
1 Department of Pediatric Neurology, Health Sciences University, Izmir Tepecik Training and Research Hospital.
2 Department of Pediatric Neurology, Izmir Katip Celebi University, Izmir.
3 Department of Pediatric Neurology, Necip Fazıl State Hospital, Kahramanmaras.
4 Genetic Diagnostic Center.
5 Department of Radiology, Health Sciences University, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.