HSP and its ‘cousin’ CMT

Posted - March 2012 in Research Highlights

People with Charcot-Marie-Tooth condition (CMT) often share some similar symptoms with HSPers. This study is now comparing both the genetics and the impaired cellular functions of the two conditions.


In this review we focus on Charcot-Marie-Tooth (CMT) neuropathies and hereditary spastic paraplegias (HSPs). Although these diseases differ in whether they primarily affect the peripheral or central nervous system, both are genetically determined, progressive, long axonopathies that affect motor and sensory pathways. This commonality suggests that there might be similarities in the molecular pathology underlying these conditions, and here we compare the molecular genetics and cellular pathology of the two groups.


SOURCE:  Exp Neurol. 2012 Jan 18. [Epub ahead of print] Copyright © 2012 Elsevier Inc. All rights reserved.  PMID: 22285450 [PubMed – as supplied by publisher]


Overlapping molecular pathological themes link Charcot-Marie-Tooth neuropathies and hereditary spastic paraplegias.


Timmerman V, Clowes VE, Reid E.


Peripheral Neuropathy Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium & Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerpen, Belgium.



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