HSPs linked to lysosome defects

Some commonalities with Alzheimer’s


Altered lysosome function and trafficking may be critical in causing some HSPs. Lysosome defects are associated with different HSP disease-causing mechanisms.



Hereditary Spastic Paraplegias (HSPs) are a genetically diverse group of inherited neurological diseases with over 80 associated gene loci. Over the last decade, research into mechanisms underlying HSPs has led to an emerging interest in lysosome dysfunction.

In this review, we highlight the different classes of HSPs that have been linked to lysosome defects:

(1) a subset of complex HSPs where mutations in lysosomal genes are causally linked to the diseases

(2) other complex HSPs where mutation in genes encoding membrane trafficking adaptors lead to lysosomal defects, and

(3) a subset of HSPs where mutations affect genes encoding proteins whose function is primarily linked to a different cellular component or organelle such as microtubule severing and Endoplasmic Reticulum-shaping, while also altering to lysosomes.

Interestingly, aberrant axonal lysosomes, associated with the latter two subsets of HSPs, are a key feature observed in other neurodegenerative diseases such as Alzheimer’s disease.

We discuss how altered lysosome function and trafficking may be a critical contributor to HSP pathology and highlight the need for examining these features in the cortico-spinal motor neurons of HSP mutant models.


SOURCE: Brain Sci. 2021 Jan 24;11(2):152. doi: 10.3390/brainsci11020152. PMID: 33498913

Lysosome Function and Dysfunction in Hereditary Spastic Paraplegias

Daisy Edmison  1 Luyu Wang  1 Swetha Gowrishankar  1

1 Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

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