Lack of movement has negative impacts

Posted - September 2018 in Living with HSP - Management & Treatment News

Brain and nerves affected


Low levels of movement, muscle disuse and lack of exercise are linked to impaired brain metabolism, motor neurons and their interaction with muscle cells.


The overall message is the importance of movement of whatever sort in helping maintain brain and nerve function, maximising mobility and quality of life.


Activity and movement are vital!



Both astronauts and patients affected by chronic movement-limiting pathologies face impairment in muscle and/or brain performance. Increased patient survival expectations and the expected longer stays in space by astronauts may result in prolonged motor deprivation and consequent pathological effects.


Severe movement limitation can influence not only the motor and metabolic systems but also the nervous system, altering neurogenesis and the interaction between motor neurons and muscle cells. Little information is yet available about the effect of prolonged muscle disuse on neural stem cells  characteristics.


Our in vitro study aims to fill this gap by focusing on the biological and molecular properties of neural stem cells (NSCs). Our analysis of NSCs derived from the SVZ of HU mice show a reduced proliferation capability and an altered cell cycle. Furthermore, NSCs obtained from HU animals present an incomplete differentiation/maturation.


The overall results support the existence of a link between reduction of exercise and muscle disuse, and metabolism in the brain and thus represent valuable new information that could clarify how circumstances such as the absence of load and the lack of movement that occurs in people with some neurological diseases, may affect the properties of NSCs and contribute to the negative manifestations of these conditions.


SOURCE: Front Neurosci. 2018 May 23;12:336. doi: 10.3389/fnins.2018.00336. eCollection 2018. PMID: 29875623


Reduction of Movement in Neurological Diseases: Effects on Neural Stem Cells Characteristics.

Adami R1, Pagano J1, Colombo M1, Platonova N1, Recchia D2, Chiaramonte R1, Bottinelli R2, Canepari M2, Bottai D1.

1 Department of Health Science, University of Milan, Milan, Italy.

2 Department of Molecular Medicine, University of Pavia, Pavia, Italy.


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