Research Highlights

Large study of SPG7 HSP

Posted - June 2019 in Research Highlights

Genotype-phenotype correlations described

SPG48 HSP studies in mice

Posted - in Research Highlights

Disease mechanism described

New brain imaging technology delivers

Posted - in Research Highlights

Brain Stem Atlas identifies SPG7 changes

SPG9 HSP linked with other conditions

Posted - in Research Highlights

Common mechanism discovered

Different approach to genetic detection

Posted - in Research Highlights

Success in 40% of cases

POLR3A gene related syndromes include HSP

Posted - in Research Highlights

Large Norwegian study confirms earlier research

New HSP genotypes and phenotypes

Posted - in Research Highlights

Research from Iran, USA, Italy, Germany, Spain, Bulgaria, Canada, Austria, Saudi Arabia, China, Ireland and Finland

Huge French study of SPG4 HSP

Posted - February 2019 in Research Highlights

New findings made

30-40% genetic diagnosis gap in HSPs

Posted - in Research Highlights

Need to look elsewhere for full picture of HSP genetics

Neurons more complex than thought

Posted - in Research Highlights

Prompts new view of how they function

Conventional view of SPG4 cause challenged

Posted - in Research Highlights

Additional mechanism suggested

New genetic type of HSP discovered

Posted - in Research Highlights

Associated with joint deformities in the feet and hands

Spinal cord changes in pure HSP

Posted - in Research Highlights

Matches with leg muscles affected

Damage in SPG4 extends to nerves of the feet

Posted - in Research Highlights

Measured by lack of sweating response

Spatial relationships different in SPG4 HSP brain

Posted - in Research Highlights

Size of difference related to clinical disability

New HSP genotypes and phenotypes

Posted - in Research Highlights

Research from China, Japan, Denmark, Czech Republic, Italy, Canada, Saudi Arabia, the UK and Portugal

Overview of the HSPs

Posted - December 2018 in Research Highlights

Call for new classification

Complex new disease includes HSP

Posted - in Research Highlights

Gene not previously linked to disease

Potential treatment for SPG2 type HSP

Posted - in Research Highlights

Good result from mice study

NIPA1 (SPG6) gene also associated with MND

Posted - in Research Highlights

Mutational repeats key factor