Research Highlights

Questioning disease classification systems

Posted - June 2017 in Research Highlights

A mechanistically inspired classification proposed

Particular form of Spastin is toxic

Posted - in Research Highlights

Interferes with fast axonal transport

Axonal degeneration in HSP

Posted - in Research Highlights

Link between different classes of HSP proteins

SPG11 mutations observed in HSP, ALS and CMT

Posted - in Research Highlights

Common mechanism of lipid accumulation in lysosomes

Impairment of Atlastin protein causes SPG3A type HSP

Posted - in Research Highlights

Important role in the regeneration of neurons disrupted

So-called Junk DNA not really junk

Posted - in Research Highlights

Junk DNA mutations found to cause HSP

More than 60 mutations exist for SPG3A HSP

Posted - in Research Highlights

Can’t predict symptom profile in this HSP type

New HSP genetic findings

Posted - in Research Highlights

From Mali, Norway, Germany, Qatar, Italy, Turkey, Saudi Arabia, Pakistan, USA, Poland

Mitochondrial dysfunction in SPG31 HSP

Posted - February 2017 in Research Highlights

Function restored in cell samples

Two siblings with blood disorder and HSP

Posted - in Research Highlights

Both conditions autosomal recessive inheritance

Large national HSP database in Canada

Posted - in Research Highlights

Valuable resource for much-needed research

SPG42 HSP mechanism now well understood

Posted - in Research Highlights

Study of mice confirms earlier findings

Complicated form of HSP linked to new gene

Posted - in Research Highlights

Impaired lipid metabolism mechanism

SPG78 HSP mechanism investigated

Posted - in Research Highlights

Pathway leads to sell organelle impairment

New HSP genetic findings

Posted - in Research Highlights

From China, the Middle East, Italy and France

Severe pain and HSP

Posted - December 2016 in Research Highlights

Different types found

New HSP mechanism discovered

Posted - in Research Highlights

Potassium ion channel dysfunction

The role of proteins in axon regeneration

Posted - in Research Highlights

Spastin and Atlastin mechanism investigated

HSP cell abnormalities

Posted - in Research Highlights

Lipid droplet metabolism important

SPG57 HSP new findings

Posted - in Research Highlights

Mitochondrial impairment the cause