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Research Highlights

Potential drug treatment for SPG5

Corrects lipid disturbance & axon degeneration in stem cells

Promising SPG4 biomarker in blood samples

Biomarker matches drug levels in mouse brain tissue

Four distinct adult HSP gait patterns identified

May assist outcome measures in clinical trials

Successful SPG4 diagnosis without genetic test

Imaging-based method a potential biomarker

Potential blood biomarker for SPG28 identified

Biochemical studies shed light on disease mechanism

Mitochondrial dysfunction in HSPs & Ataxias

Disease-causing mechanisms described

New light shed on SPG78 mechanism

Multi-faceted studies the key

Function of PCYT2 gene (SPG82) studied

Key enzyme in muscle health and degeneration

New HSP genotypes & phenotypes

Research from Iran, Germany, Canada, Sweden, Sudan, France, China, South Korea, India

Gait changes measure HSP progression

Evidence established in large study

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HSP Research Foundation

Welcome to the HSP Research Foundation - created in 2005 to find a cure for Hereditary Spastic Paraplegia - an inherited, degenerative disease affecting mainly the legs, causing muscle weakness, spasticity and severely impairing walking. Read more »

Information on this website and resources to which we have links are general knowledge about HSP. We are not medical professionals, nor do we offer medical advice. Always consult your own medical professionals regarding your particular circumstances.

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The HSP Research Foundation Incorporated ABN 46648875912 is an Income Tax Exempt Charity endorsed by the ATO as a Deductible Gift Recipient organisation.

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