Spastin, implicated in microtubule-severing activity, is now implicated in forming bundles of microtubules
Recent evidence confirmed that spastin possesses microtubule-severing activity but can also bundle microtubules in vitro. Understanding the physiologic and pathologic involvement of these activities and their regulation is critical in the study of HSP.
SPG4, the gene encoding for spastin, a member of the ATPases associated with various cellular activities (AAA) family, is mutated in around 40% of cases of autosomal dominant hereditary spastic paraplegia (AD-HSP). This group of neurodegenerative diseases is characterized by a progressive spasticity and lower limb weakness with degeneration of terminal axons in cortico-spinal tracts and dorsal columns. Spastin has two main domains, a microtubule interacting and endosomal trafficking (MIT) domain at the N-terminus and the C-terminus AAA domain. Early studies suggested that spastin interacts with microtubules similarly to katanin, a member of the same subgroup of AAA. (c) 2007 Wiley-Liss, Inc.
SOURCE: J Neurosci Res. 2007 Sep;85(12):2778-82.
Spastin and microtubules: Functions in health and disease.
Salinas S, Carazo-Salas RE, Proukakis C, Schiavo G, Warner TT.
Molecular NeuroPathobiology, Cancer Research United Kingdom London Research Institute, Lincoln’s Inn Fields Laboratories, London, UK.
PMID: 17348041 [PubMed – indexed for MEDLINE]