SPATAX – research collaboration

Clinical and genetic databases developed


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The SPATAX network combines the experience of European clinicians and scientists working on cerebellar ataxias and spastic paraplegias. The network was created in the year 2000 and now includes over 20 teams in 19 countries.


Since forming, they have assembled the largest collection of HSP family histories and achieved a number of important milestones – initiation of a clinical and genetic database, distribution of DNA to participating laboratories, mapping of at least three new HSP loci, and refinement of several loci.


Clinicians from European and Mediterranean countries play a major role in collecting family data according to evaluation tools developed and validated by the SPATAX members. The group includes major European laboratories devoted to the elucidation of the molecular basis of these disorders.


Their intent is that the assembled patient data and the precise knowledge of natural history will facilitate the implementation of therapeutic trials based on rational approaches.


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