Spatial relationships different in SPG4 HSP brain

Posted - February 2019 in Research Highlights

Size of difference related to clinical disability

 

Abstract

AIM: Our aim was to describe the rearrangements of the brain activity related to genetic mutations in the SPAST gene.

 

METHODS: Ten SPG4 patients and ten controls underwent a 5 min resting state magnetoencephalography recording and neurological examination. A beamformer algorithm reconstructed the activity of 90 brain areas. The phase lag index was used to estimate synchrony between brain areas. The minimum spanning tree was used to estimate topological metrics such as the leaf fraction (a measure of network integration) and the degree divergence (a measure of the resilience of the network against pathological events). The betweenness centrality (a measure to estimate the centrality of the brain areas) was used to estimate the centrality of each brain area.

 

RESULTS: Our results showed topological rearrangements in the beta band. Specifically, the degree divergence was lower in patients as compared to controls and this parameter related to clinical disability. No differences appeared in leaf fraction nor in betweenness centrality.

 

CONCLUSION: Mutations in the SPAST gene are related to a reorganization of the brain topology.

 

SOURCE: Neurol Sci. 2019 Feb 8. doi: 10.1007/s10072-019-3725-y. [Epub ahead of print] PMID: 30737580

 

Mutations in the SPAST gene causing hereditary spastic paraplegia are related to global topological alterations in brain functional networks.

 

Rucco R1,2, Liparoti M3, Jacini F3,4, Baselice F5, Antenora A6, De Michele G6, Criscuolo C7, Vettoliere A2, Mandolesi L8, Sorrentino G9,10, Sorrentino P2,5.

1 Department of Science and Technology, University of Naples Parthenope, Naples, Italy.

2 Institute of Applied Sciences and Intelligent Systems, CNR, Pozzuoli, Italy.

3 Department of Motor Sciences and Wellness, University of Naples Parthenope, Via Medina 38, 80133, Naples, Italy.

4 Hermitage-Capodimonte Hospital, Naples, Italy.

5 Department of Engineering, University of Naples Parthenope, Naples, Italy.

6 Department of Neurosciences, Reproductive, and Odontostomatological Sciences, University of Naples Federico II, Policlinico Hospital, Building 17, Via S. Pansini 5, 80131, Naples, Italy.

7 Department of Neurosciences, Reproductive, and Odontostomatological Sciences, University of Naples Federico II, Policlinico Hospital, Building 17, Via S. Pansini 5, 80131, Naples, Italy. [email protected]

8 Department of Humanistic Studies, University of Naples Federico II, Naples, Italy.

9 Department of Motor Sciences and Wellness, University of Naples Parthenope, Via Medina 38, 80133, Naples, Italy. [email protected]

10 Hermitage-Capodimonte Hospital, Naples, Italy. [email protected]

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