AP-4 blood biomarker discovered also
Author: Editor
Potential imaging biomarkers of HSP progression
Peripheral nerve involvement in SPG4 & SPG7
Lipid balance disrupted in SPG89
Approved statins may help fix the problem
Computer simulation of gait in early-stage SPG4
Marker of disease severity / treatment effectiveness
Methodology established to quantify gait in HSP
Single lower-back wearable inertial sensor used
Is it HSP, CMT, PLS or ALS?
Gene testing helps with diagnosis
Mouse study of SPG8 disease mechanism
Protein regulates structural plasticity of neurons
High phenotype variability in SPG3A examined
Other genes & epigenetics play a part
New HSP genotypes & phenotypes
Research from Taiwan, Spain, China, France, USA, South Korea, Italy, Turkiye, India and Brazil
AKV9 (NU-9) approved for clinical trial
Phase 1 study in humans