AP-4 blood biomarker discovered also
Research Highlights
Potential imaging biomarkers of HSP progression
Peripheral nerve involvement in SPG4 & SPG7
Lipid balance disrupted in SPG89
Approved statins may help fix the problem
Computer simulation of gait in early-stage SPG4
Marker of disease severity / treatment effectiveness
Methodology established to quantify gait in HSP
Single lower-back wearable inertial sensor used
Is it HSP, CMT, PLS or ALS?
Gene testing helps with diagnosis
Mouse study of SPG8 disease mechanism
Protein regulates structural plasticity of neurons
High phenotype variability in SPG3A examined
Other genes & epigenetics play a part
New HSP genotypes & phenotypes
Research from Taiwan, Spain, China, France, USA, South Korea, Italy, Turkiye, India and Brazil
Potential drug treatment for SPG5
Corrects lipid disturbance & axon degeneration in stem cells