Comprehensive characterisation established
Research Highlights
Calcium balance disrupted in SPG4 HSP
Relevant to disease mechanism
Clinical gait analysis tells HSP from CP
Machine learning the key
RNA technologies for neurodegenerative diseases
Advantages and challenges
SPG87 mechanism findings
Lipid processing, ER & mitochondria involved
New HSP genotypes and phenotypes
Research from USA, Germany, Brazil, UK, China, Taiwan, Iran, Azerbaijan, Pakistan
Gene therapy under development for SPG49
Successfully tested in primates
Neuroinflammation important in SPG11
Responsive to drug treatment in animal testing
Neuropsychology of SPG11 studied
Verbal fluency, memory & executive functions impaired
SPG3A & MS found in 9 cases
Positive response to immunotherapy for most