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Research Highlights

Detailed study of SPG15 HSP

Comprehensive characterisation established

Calcium balance disrupted in SPG4 HSP

Relevant to disease mechanism

Clinical gait analysis tells HSP from CP

Machine learning the key

RNA technologies for neurodegenerative diseases

Advantages and challenges

SPG87 mechanism findings

Lipid processing, ER & mitochondria involved

New HSP genotypes and phenotypes

Research from USA, Germany, Brazil, UK, China, Taiwan, Iran, Azerbaijan, Pakistan

Gene therapy under development for SPG49

Successfully tested in primates

Neuroinflammation important in SPG11

Responsive to drug treatment in animal testing

Neuropsychology of SPG11 studied

Verbal fluency, memory & executive functions impaired

SPG3A & MS found in 9 cases

Positive response to immunotherapy for most

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HSP Research Foundation

Welcome to the HSP Research Foundation - created in 2005 to find a cure for Hereditary Spastic Paraplegia - an inherited, degenerative disease affecting mainly the legs, causing muscle weakness, spasticity and severely impairing walking. Read more »

Information on this website and resources to which we have links are general knowledge about HSP. We are not medical professionals, nor do we offer medical advice. Always consult your own medical professionals regarding your particular circumstances.

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The HSP Research Foundation Incorporated ABN 46648875912 is an Income Tax Exempt Charity endorsed by the ATO as a Deductible Gift Recipient organisation.

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