Research Highlights

New HSP genotypes and phenotypes

Posted - May 2020 in Research Highlights

Research from Poland, Sudan, Spain, Iran, Korea, China, Czech Republic, Taiwan, Turkey, Mexico and Italy

Earlier HSP onset in successive generations

Posted - February 2020 in Research Highlights

Missense mutations also related to earlier onset

Potential treatment for SPG5 HSP identified

Posted - in Research Highlights

Promising results in mouse studies

New SPG4 disease pathway identified

Posted - in Research Highlights

Mechanism unrelated to microtubule-severing ability

SPG31 studied in fruit flies

Posted - in Research Highlights

Flavonoid treatment restores impaired function

Review of 147 HSP studies of 13,570 HSPers

Posted - in Research Highlights

Revealing big picture overview

New HSP genotypes and phenotypes

Posted - in Research Highlights

Research from Russia, China, Japan, Poland, Italy, Canada, Czech Republic, Spain, the UK and Iran

Search for biomarker of complicated HSP

Posted - in Research Highlights

Retinal nerve fibre thickness studied

Special imaging shows differences due to HSP

Posted - December 2019 in Research Highlights

Potential as a biomarker of progression

New HSP gene PCYT2

Posted - in Research Highlights

Associated with recessive, complicated HSP

Suspected new HSP gene SPTAN1

Posted - in Research Highlights

Huge HSP genetics study in Canada

Two studies of SPG7

Posted - in Research Highlights

Parkinsonism and a potential eye movement biomarker

SPG30 mechanism clarified

Posted - in Research Highlights

Increased, not decreased, activity found

SPG2 has a hugely variable presentation

Posted - in Research Highlights

“Neighbour” genes involved in complex, early-onset forms

SPG13 mechanism described

Posted - in Research Highlights

Same gene & mechanism causes another disorder

New HSP genotypes and phenotypes

Posted - in Research Highlights

Research from The Netherlands, Sweden, Russia, USA, Italy, Brazil, UK, Japan, France, Switzerland, Germany, Tunisia, Iran, China, Turkey

Advances in understanding of the HSPs

Posted - September 2019 in Research Highlights

Insight into impaired functions and underlying mechanisms

Three rapid tests of HSP features developed

Posted - in Research Highlights

Potential drug target for SPG4 identified

New explanation for SPG4 causal mechanism

Posted - in Research Highlights

Both too little & too much Spastin to blame

Mitochondrial dynamics and HSP axon defects

Posted - in Research Highlights

Corrected by having less of key protein DRP1