Biomarker matches drug levels in mouse brain tissue
Research Highlights
Four distinct adult HSP gait patterns identified
May assist outcome measures in clinical trials
Successful SPG4 diagnosis without genetic test
Imaging-based method a potential biomarker
Potential blood biomarker for SPG28 identified
Biochemical studies shed light on disease mechanism
Mitochondrial dysfunction in HSPs & Ataxias
Disease-causing mechanisms described
New light shed on SPG78 mechanism
Multi-faceted studies the key
Function of PCYT2 gene (SPG82) studied
Key enzyme in muscle health and degeneration
New HSP genotypes & phenotypes
Research from Iran, Germany, Canada, Sweden, Sudan, France, China, South Korea, India
Gait changes measure HSP progression
Evidence established in large study
Speech impairment frequent and mild in SPG4
Speech therapy evaluation recommended