Found to cause complex HSP in 3 children
Research Highlights
Body, blood and brain changes in SPG 11
Metabolic therapies may have potential
Mouse & human symptoms linked in SPG47
Potential for testing therapies
New HSP genotypes & phenotypes
Research from China, Mali, India, Taiwan, Russia, Saudi Arabia
SPG15 HSP disease mechanism defined
Drug candidates for treatment identified
Vast differences in SPG4 HSP explained
Disruption to another gene SARS2 identified
Predicting disease onset in SPG4 HSP
Particular features of gait identified
Promising gene therapy developed
Effective for DNM2 related diseases including SPG
Detailed study of SPG15 HSP
Comprehensive characterisation established
Calcium balance disrupted in SPG4 HSP
Relevant to disease mechanism