From Hungary, Sudan, Australia and China
Research Highlights
Australian success with whole genome sequencing
Higher detection rates for HSP mutations
Recessive SPG35 HSP inherited from just one parent
Major implications for genetic counselling
Large Czech study of SPAST HSP
327 HSPers from 263 families gene tested
FARS2 gene mutation described
Causes recessive but pure SPG77 HSP
HSPer also found to have MS
First description of dual occurrence
Pure HSP study of children in Greece
Clinical and genetic findings
New HSP genetic findings
From Iran, Germany, China, Greece, Japan, Pakistan and Hungary
SPAST (SPG4) HSP mechanism explained
Potential drug treatment identified
Potential therapeutic avenues for HSP
Biomarkers investigated in animal models