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Research Highlights

Nerve abnormalities in HSP

Problems for some in the feet and legs

Nerve damage in SPG11 studied

Both white and grey matter damage found

HSP-impaired cell functions studied

Importance of Reticulon protein demonstrated

SPG31/REEP1 study of cell function

Abnormal mitochondrial organization and function

Spastin (SPG4) regulatory mechanisms studied

New targets found for mutation and drug screening

HSP and brain tissue damage

Found in both pure and complicated HSP

Measuring functional mobility in HSPers

Tools selected for Melbourne Gait Study

52 forms of HSP have now been found

Described by mode of inheritance

Spastin / Protrudin partnership studied

Role in normal neuron growth

Treatment helps symptoms for some SPG11 HSP

Improvement in walking

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HSP Research Foundation

Welcome to the HSP Research Foundation - created in 2005 to find a cure for Hereditary Spastic Paraplegia - an inherited, degenerative disease affecting mainly the legs, causing muscle weakness, spasticity and severely impairing walking. Read more »

Information on this website and resources to which we have links are general knowledge about HSP. We are not medical professionals, nor do we offer medical advice. Always consult your own medical professionals regarding your particular circumstances.

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