Problems for some in the feet and legs
Research Highlights
Nerve damage in SPG11 studied
Both white and grey matter damage found
HSP-impaired cell functions studied
Importance of Reticulon protein demonstrated
SPG31/REEP1 study of cell function
Abnormal mitochondrial organization and function
Spastin (SPG4) regulatory mechanisms studied
New targets found for mutation and drug screening
HSP and brain tissue damage
Found in both pure and complicated HSP
Measuring functional mobility in HSPers
Tools selected for Melbourne Gait Study
52 forms of HSP have now been found
Described by mode of inheritance
Spastin / Protrudin partnership studied
Role in normal neuron growth
Treatment helps symptoms for some SPG11 HSP
Improvement in walking
