New findings made
Research Highlights
30-40% genetic diagnosis gap in HSPs
Need to look elsewhere for full picture of HSP genetics
Neurons more complex than thought
Prompts new view of how they function
Conventional view of SPG4 cause challenged
Additional mechanism suggested
New genetic type of HSP discovered
Associated with joint deformities in the feet and hands
Spinal cord changes in pure HSP
Matches with leg muscles affected
Damage in SPG4 extends to nerves of the feet
Measured by lack of sweating response
Spatial relationships different in SPG4 HSP brain
Size of difference related to clinical disability
New HSP genotypes and phenotypes
Research from China, Japan, Denmark, Czech Republic, Italy, Canada, Saudi Arabia, the UK and Portugal
Overview of the HSPs
Call for new classification