Research Highlights

Exome sequencing helps with HSP diagnosis

Posted - June 2016 in Research Highlights

New gene-disease associations found

The science of patient input

Posted - in Research Highlights

Integrating patient needs and priorities

New Findings on SPG11 HSP mechanism

Posted - in Research Highlights

Potential treatment target identified

Late-onset spastic paraplegia type 10 (SPG10)

Posted - May 2016 in Research Highlights

First-time discovered in an Asian family

REEP1 (SPG31) found with recessive inheritance

Posted - in Research Highlights

Previously associated only with dominant form

New HSP genetic findings

Posted - in Research Highlights

From Japan, Poland, England, China, Hungary, Morocco, Canada, Italy and the USA

Developing a ‘natural history’ of HSP

Posted - February 2016 in Research Highlights

Large German study lays the foundation

Atlastin (SPG 3A) investigated

Posted - in Research Highlights

Questions raised about regulation and role

SPG 8 HSP loss-of-function theory questioned

Posted - in Research Highlights

Implications for alternative gain-of-function hypothesis

Brain shrinkage found in SPG 2 HSP

Posted - in Research Highlights

Changes also in the myelin sheath around axons

Mechanism of complicated SPG49 HSP studied

Posted - in Research Highlights

TECPR2 protein deficiency affects multiple cell functions

New HSP genetics findings

Posted - in Research Highlights

From Germany, Norway, Pakistan, China, Japan

HSP research update December 2015

Posted - December 2015 in Research Highlights

Progress report from the research team

Focus on SPG11 HSP

Posted - in Research Highlights

Three research studies reviewed

Protein interactions and nerve myelination

Posted - in Research Highlights

Helping understand more about SPG2 HSP

More overlap between HSP and CMT discovered

Posted - in Research Highlights

New gene for HSP implicated

New HSP genetics findings

Posted - in Research Highlights

From Japan, Greece, Belgium, Turkey, Italy, Canada

Promising results in HSP drug candidate class

Posted - September 2015 in Research Highlights

Nerve axon regeneration and improved motor function

What is now known about SPG4 HSP

Posted - in Research Highlights

More answers, but also more questions

Brain changes in SPG4 HSP measured

Posted - in Research Highlights

Correlated with disease duration and severity