Shedding light on treatment targets
Research Highlights
AP-4 related childhood-onset, complex HSP
Covers SPG47, SPG50, SPG51 and SPG52
ER stress associated with SPG31
Mice with SPG31 have functions restored with treatment
Impaired mitochondria SPG61
Division (fission) problems in mitochondrial network
Lower motor neuron degeneration in HSP?
Findings of electrophysiological studies
New HSP genotypes & phenotypes
Research from the Netherlands, China, Hungary, USA, Republic of Korea, Chile, Germany, Argentina, Japan, Peru, Spain, France and Brazil
Mitochondrial function study in HSP
New findings about SPG7 and SPG4
Why genetic diagnosis rates still so low in HSP
Limitations of genetic testing technology
Large study of childhood-onset HSPs
Challenges in diagnosis experienced
Mechanism of SPG46 studied
Structure and function of mitochondria affected