Research from Germany, UK, Taiwan, Sweden, Italy, Saudi Arabia, China, Czech Republic, Iran, USA, Austria, Belgium, the Netherlands, Egypt, Pakistan, France, Japan, Turkey, Russia, Ireland, India
Research Highlights
Vital role of lipids in upper motor neurons
Implications for HSP and its treatment
Lipid disruption key in SPG3A cells
Impaired cholesterol metabolism restored
Mild cognitive impairment in some SPG11
Study of sporadic, late-onset cases
Spinal cord damage in HSP
Marked differences between HSP types
Significant brain changes in pure HSP
Potential biomarker of disease progression
HSPs linked to lysosome defects
Some commonalities with Alzheimer’s
New HSP-associated gene FAR1
AD form with different disease mechanism
New HSP genotypes and phenotypes
Research from China, Australia, Greece, the UK, Republic of Moldova, France, Cyprus, Italy, the USA, Japan, Sweden, Algeria, Portugal, Turkey, Belgium and India
Cell mechanism behind SPG7 discovered
Drug treatment to correct impairment identified